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KMID : 0613820080180101336
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Journal of Life Science
2008 Volume.18 No. 10 p.1336 ~ p.1341
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Amelioration of Asthmatic-Related Symptoms by an Aqueous Extract of Angelica archangelica L.
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Heo Jin-Chul
Lee Sang-Han
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Abstract
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Inflammation through the respiratory tract is a crucial event in immune disorders, including asthma, and atopic rhinitis. To investigate whether an aqueous extract of Angelica archangelica L. (AaL) has a beneficial influence in terms of anti-asthmatic activity, its effects on an ovalbumin-induced asthmatic model were examined. Mice sensitized to ovalbumin were orally administered the AaL extract, and their lungs examined by Haematoxylin-Eosin staining to determine IL-4/13 cytokine expression. The AaL extract exerted strong anti-asthmatic effects by regulating each level in the CD4+ cell number, IL-4/13, and other target markers in the lungs. Together, these results collectively indicate that the aqueous AaL extract ameliorates asthmatic symptoms effectively in a mouse ovalbumin-challenge model.
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KEYWORD
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Angelica archangelica L., asthma, inflammation, aqueous extract, ovalbumin-challenge model
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